Recent Publications

Recent Publications

For manuscripts published prior to 2013, please see a complete list of publications via PubMed.


Paul A. Insel, Krishna Sriram, Shu Z. Wiley, Andrea Wilderman, Trishna Katakia, Thalia McCann, Hiroshi Yokouchi, Lingzhi Zhang, Ross Corriden, Dongling Liu, Michael E. Feigin, Randall P. French, Andrew M. Lowy and Fiona Murray GPCRomics: GPCR Expression in Cancer Cells and Tumors IdentifiesNew, Potential Biomarkers and Therapeutic Targets Frontiers in Pharmacology. 2018 May 22. PubMed PMID: 29872392 [PubMed]

Sriram K, Insel PA G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? ASPET Molecular Pharmacology. 2018 April. PubMed PMID: 292988213 [PubMed]

Shu Z. Wiley, Krishna Sriram, Wenjing Liang, Sarah E. Chang, Randall French,Thalia McCann, Jason Sicklick,,Hiroshi Nishihara, Andrew M. Lowy, and Paul A. Insel GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells FASEB Journal. 2018 March 9. PubMed PMID: 29092903 [PubMed]


Wilderman A, Guo Y, Divakaruni A, Perkins G, Zhang L, Murphy A, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Jul 22. PubMed PMID: 26203188. [HTML]
Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor. Ann Clin Transl Neurol. 2015 Jun;2(6):595-608.  PubMed PMID: 26125036. [HTML]
Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SP, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LD, Wonnacott S, Weston AH, McGrath JC. Experimental design and analysis and their reporting: new guidance for publication in BJP. Br J Pharmacol. 2015 Jul;172(14):3461-71. PubMed PMID: 26114403. [HTML]
Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul;88(1):139-40. PubMed PMID: 25943115. [HTML]
Overland AC, Insel PA. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. J Biol Chem. 2015 Apr 17;290(16):9941-7. PubMed PMID: 25759388. [HTML]
Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: “Novel” endoGPCRs as Physiologic Regulators and Therapeutic Targets. Mol Pharmacol. 2015 Jul;88(1):181-7. PubMed PMID: 25737495. [HTML]
Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1529-34. doi: 10.1073/pnas.1417972112. PubMed PMID: 25605931. [HTML]
Insel PA, Amara SG, Blaschke TF. Introduction to the theme “Precision medicine and prediction in pharmacology”. Annu Rev Pharmacol Toxicol. 2015;55:11-4. PubMed PMID: 25562643. [HTML]


Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel PA. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. J Biol Chem. 2014 Oct 17;289(42):29148-57.   PubMed PMID: 25183009. [HTML]
Insel PA, Wilderman A, Zhang L, Keshwani MM, Zambon AC. Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells. Horm Metab Res. 2014 Nov;46(12):854-62. doi: 10.1055/s-0034-1384519. Epub 2014 Jul 16. PubMed PMID: 25028794. [HTML]
Foufelle F, Lotersztajn S, Insel PA, Chevet E. AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C581. PubMed PMID: 24990648. [HTML]
Fridolfsson HN, Roth DM, Insel PA, Patel HH. Regulation of intracellular signaling and function by caveolin. FASEB J. 2014 Sep;28(9):3823-31. PubMed PMID: 24858278. [HTML]
Brown LM, Rogers KE, McCammon JA, Insel PA. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition. J Biol Chem. 2014 Mar 21;289(12):8217-30. PubMed PMID: 24497631. [HTML]
Lu D, Insel PA. Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. Am J Physiol Cell Physiol. 2014 May 1;306(9):C779-88. PubMed PMID: 24352335. [HTML]
Fuller CM, Insel PA. I don’t know the question, but sex is definitely the answer! Focus on “In pursuit of scientific excellence: sex matters” and “Do you know the sex of your cells?”. Am J Physiol Cell Physiol. 2014 Jan 1;306(1):C1-2. PubMed PMID: 24225885. [HTML]


Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol. 2013 Dec;84(6):787-93. PubMed PMID: 24085841. [HTML]
McCarty OJ, King MR, Insel PA. A theme series on physical biology in cancer in AJP-Cell. Am J Physiol Cell Physiol. 2014 Jan 15;306(2):C77. PubMed PMID: 24067917. [HTML]
Head BP, Patel HH, Insel PA. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta. 2014 Feb;1838(2):532-45. PubMed PMID: 23899502. [HTML]
Torday JS, Insel PA. AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology. Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C681. PubMed PMID: 23824845. [HTML]
Goldberg C, Insel PA. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Acad Med. 2013 Jun;88(6):745-7. PubMed PMID: 23708597. [HTML]
Lu D, Insel PA. Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. J Biol Chem. 2013 Jun 28;288(26):19040-9. PubMed PMID: 23677997. [HTML]
Murray F, Insel PA. Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma. Expert Opin Ther Targets. 2013 Aug;17(8):937-49. PubMed PMID: 23647244. [HTML]
Lotersztajn S, Insel PA. AJP-Cell begins a theme series on tissue fibrosis. Am J Physiol Cell Physiol. 2013 Feb 1;304(3):C215. PubMed PMID: 23255579. [HTML]


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