About Us

About Us

Our lab’s research focuses on G-protein-coupled receptors (GPCRs) and their signaling mechanisms with an emphasis on receptor expression and regulation, post-receptor signal transduction events/components and downstream responses. Much of our current efforts use GPCRomic approaches to define the profile of GPCRs expressed by individual cell types and to compare these profiles between normal and diseased cells. Cell types of current interest include fibroblasts (cardiac, pulmonary, dermal, and cancer-associated fibroblasts), cardiac myocytes (including myocytes derived for iPS cells), pulmonary arterial smooth muscle cells, neutrophils, dendritic cells, lymphoid cells, adipocytes and certain cancer cells (e.g., chronic lymphocytic leukemia cells and pancreatic ductal adenocarcinoma cells). Disease settings of particular interest include tissue fibrosis, pulmonary arterial hypertension, and pancreatic cancer. Through these efforts, we seek to identify previously unrecognized GPCRs as regulators of cell function and as novel therapeutic targets. Other recent work seeks to define the role of lipid raft/caveolae membrane microdomains in GPCR signaling, matrix metalloproteinase 14, (MMP14, MT1-MMP) activation by heterotrimeric G-proteins, and mechanisms of cyclic AMP action (in particular, as related to apoptotic cell death, dendritic cell regulation of T cells, and the actions of protein kinase A and the Exchange protein activated by cyclic AMP [Epac]). We actively collaborate with numerous labs within and outside of UCSD.

Lab Personnel

Publications

Contact Us